Histamine receptors in rabbit basilar artery.
نویسندگان
چکیده
منابع مشابه
Manipulation of chloride flux affects histamine-induced contraction in rabbit basilar artery.
Cl(-) efflux induces depolarization and contraction of smooth muscle cells. This study was undertaken to explore the role of Cl(-) flux in histamine-induced contraction in the rabbit basilar artery. Male New Zealand White rabbits (n = 16) weighing 1.8-2.5 kg were euthanized by an overdose of pentobarbital sodium. The basilar arteries were removed for isometric tension recording. Histamine produ...
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Actions ofFRC8653 on the macroscopic and unitary Ba2` currents were studied using the rabbit basilar artery. Application of (+)-FRC8653 (<1 ,uM) increased the amplitude of the inward current when depolarization pulses more negative than -10 mV were applied but inhibited it when depolarization was more positive than 0 mV (in each case from a holding potential of -80 mV). At a holding potential o...
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BACKGROUND AND PURPOSE Experiments were carried out in rabbits to determine whether clentiazem (8-chlorodiltiazem), a cerebrovascular-selective calcium channel blocker, administered 24 hours before subarachnoid hemorrhage influenced the subsequent cerebral vasospasm. METHODS Subarachnoid hemorrhage was induced by multiple injections of blood into the prepontine cisterns of 35 male New Zealand...
متن کاملMechanism of endothelin-1-induced contraction in rabbit basilar artery.
BACKGROUND AND PURPOSE Endothelin-1 (ET-1) is suggested to be a major cause of cerebral vasospasm after subarachnoid hemorrhage. However, the mechanism of ET-1-induced contraction in cerebral arteries remains unclear. This study was undertaken to demonstrate the possible role of protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC) in ET-1-induced co...
متن کاملNeurogenic sympathetic vasoconstriction of the rabbit basilar artery.
When examined by fluorescence microscopy the rabbit basilar artery contains a rich adrenergic-like plexus at the adventitiomedial junction. The fluorescence disappears upon chronic reserpinization and bilateral superior cervical ganglionectomy. Transmural stimulation of intramural nerves a results in a response which is predominantly constrictor but also contains a small, inconstant dilator com...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1983
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)64917-6